By Yves Pommier (Ed.),Yves Pommier
DNA topoisomerases signify a vital relations of DNA processing enzymes and plenty of topoisomerase inhibitors are used clinically for the therapy of assorted human cancers. Novels medicines are in scientific improvement either opposed to variety I and kind II topoisomerases. The e-book will comprise uncomplicated biochemical and structural experiences for the cancer-relevant topoisomerases. it is going to describe how topoisomerase dysfunctions can harm the genome and bring up the chance of cancers, and the involvement of topoisomerases in programmed telephone loss of life. The publication also will current many of the topoisomerase inhibitors in medical use and improvement and their molecular and mobile mechanisms of action.
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DNA Topoisomerases and Cancer (Cancer Drug Discovery and Development) by Yves Pommier (Ed.),Yves Pommier
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