By Jie Jack Li

ISBN-10: 0199737681

ISBN-13: 9780199737680

ISBN-10: 1522694366

ISBN-13: 9781522694366

For the world's biggest prescription drug brands, the previous couple of years were a harrowing time. lately, Pfizer's Lipitor, GlaxoSmithKline's Advair, AstraZeneca's Seroquel, and Sanofi-Aventis and Bristol-Myers Squibb's Plavix all got here off patent within the an important U.S. industry. This so-called "patent cliff" intended thousands of billions of bucks in misplaced profit and has pharmaceutical builders scrambling to create new medicines and litigating to increase present patent protections.

Having spent such a lot of his profession in drug discovery in "big pharma," Dr. Li now supplies an insider's account of the way the drug ascended to its plateau and explores the character of the turmoil it faces within the coming years. He starts off with a survey of the panorama ahead of "blockbuster drugs," and proceeds to explain how these medications have been chanced on and for that reason grew to become fundamental to the company versions of enormous pharmaceutical businesses. for instance, in early Nineteen Eighties, Tagamet, the 1st "blockbuster drug," reworked a minor Philadelphia-based drug maker named SmithKline & French into the world's ninth-largest pharmaceutical corporation when it comes to revenues. The undertaking that added Tagamet was once approximately terminated a number of occasions simply because learn efforts all started in 1964 produced no obvious effects in the first 11 years. comparable tales accompany the invention and improvement of now-ubiquitous prescribed drugs, between them Claritin, Prilosec, Nexium, Plavix, and Ambien.

These tales, and the points of the pharmaceutical that they show, can train us important classes and show many the most important facets in regards to the destiny panorama of drug discovery. As continuously, Dr. Li writes in a readable variety and intersperses attention-grabbing tales of medical discovery with enticing human drama.

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Blockbuster Drugs: The Rise and Decline of the Pharmaceutical Industry by Jie Jack Li

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